Inter-University Attraction Poles Phase VII P7/16 Network: An integrated approach towards understanding the pathogenesis of neurodegeneration

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Life sciences : An integrated approach towards understanding the pathogenesis of neurodegeneration.

The NEUROBRAINNET network aims to gain a better understanding of the process of neurodegeneration in the central nervous system (CNS) that lead to diseases such as Alzheimer disease, frontotemporal lobar degeneration, dementia with Lewy bodies, Parkinson disease and related spectrum disorders including amyotrophic lateral sclerosis. These devastating diseases, of which numbers increase with the progressing aging process in our society, have a tremendous impact on the quality of life of the patients as well as their caretakers and lead, often after a long and debilitating course, ultimately to death. Although these diseases have major socio-economical consequences worldwide, no efficient cures are yet available.

The network brings together researchers specialized in clinical neurology, neuropathology, genetics and genomics, cell biology and model organisms, protein modelling and translational research, who are active in the domain of neurodegenerative brain diseases. The partners aim at clarifying a series of fundamental scientific questions related to the pathophysiological processes underlying these diseases. More specifically, they aim at identifying biological pathways that are linked to these diseases, by identifying novel genes and genetic risk factors, by identifying modifiers of genetic function by genetic screens, by analyzing the functional networks in which the proteins encoded by these genes are operating, and ultimately, by providing novel avenues for early diagnosis, prognosis, prevention and treatment.

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    CAU Erasmus Inserm Pasteur