Inter-University Attraction Poles Phase VII P7/16 Network: An integrated approach towards understanding the pathogenesis of neurodegeneration





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IAP VII P7/16 Publications

P2. Bart De Strooper


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2016 →top

Aerts L, Craessaerts K, De Strooper B, Morais VA (2016) In Vitro Comparison of the Activity Requirements and Substrate Specificity of Human and Triboleum castaneum PINK1 Orthologues. PLoS One 11(1): e0146083 () pdf(private)

Veugelen S, Saito T, Saido TC, Chávez-Gutiérrez L, De Strooper B (2016) Familial Alzheimer's Disease Mutations in Presenilin Generate Amyloidogenic Aβ Peptide Seeds. Neuron 90(2): 410-6 () pdf(private)


2015 →top

Trovò L, Stroobants S, D'Hooge R, Ledesma MD, Dotti CG (2015) Improvement of biochemical and behavioral defects in the Niemann-Pick type A mouse by intraventricular infusion of MARCKS. Neurobiol Dis : 319-26 () pdf(private)

De Strooper B, Chávez Gutiérrez L (2015) Learning by failing: ideas and concepts to tackle γ-secretases in Alzheimer's disease and beyond. Annu Rev Pharmacol Toxicol : 419-37 () pdf(private)

Papadopoulou AS, Serneels L, Achsel T, Mandemakers W, Callaerts-Vegh Z, Dooley J, Lau P, Ayoubi T, Radaelli E, Spinazzi M, Neumann M, Hébert SS, Silahtaroglu A, Liston A, D'Hooge R, Glatzel M, De Strooper B (2015) Deficiency of the miR-29a/b-1 cluster leads to ataxic features and cerebellar alterations in mice. Neurobiol Dis : 275-88 () pdf(private)

Elad N, De Strooper B, Lismont S, Hagen W, Veugelen S, Arimon M, Horré K, Berezovska O, Sachse C, Chávez-Gutiérrez L (2015) The dynamic conformational landscape of gamma-secretase. J Cell Sci 128(3): 589-98 () pdf(private)

Valadas JS, Vos M, Verstreken P (2015) Therapeutic strategies in Parkinson's disease: what we have learned from animal models. Ann N Y Acad Sci : 16-37 () pdf(private)

Aerts L, Craessaerts K, De Strooper B, Morais VA (2015) PINK1 kinase catalytic activity is regulated by phosphorylation on serines 228 and 402. J Biol Chem 290(5): 2798-811 () pdf(private)

Peric A, Annaert W (2015) Early etiology of Alzheimer's disease: tipping the balance toward autophagy or endosomal dysfunction? Acta Neuropathol 129(3): 363-81 () pdf(private)

Schulz JG, Laranjeira A, Van Huffel L, Gärtner A, Vilain S, Bastianen J, Van Veldhoven PP, Dotti CG (2015) Glial β-oxidation regulates Drosophila energy metabolism. Sci Rep : 7805 () pdf(private)

Vanhauwaert R, Verstreken P (2015) Flies with Parkinson's disease. Exp Neurol 274(Pt A): 42-51 () pdf(private)

Aerts L, De Strooper B, Morais VA (2015) PINK1 activation-turning on a promiscuous kinase. Biochem Soc Trans 43(2): 280-6 () pdf(private)

Calafate S, Buist A, Miskiewicz K, Vijayan V, Daneels G, de Strooper B, de Wit J, Verstreken P, Moechars D (2015) Synaptic Contacts Enhance Cell-to-Cell Tau Pathology Propagation. Cell Rep 11(8): 1176-83 () pdf(private)

Huang Y, Skwarek-Maruszewska A, Horré K, Vandewyer E, Wolfs L, Snellinx A, Saito T, Radaelli E, Corthout N, Colombelli J, Lo AC, Van Aerschot L, Callaerts-Vegh Z, Trabzuni D, Bossers K, Verhaagen J, Ryten M, Munck S, D'Hooge R, Swaab DF, Hardy J, Saido TC, De Strooper B, Thathiah A (2015) Loss of GPR3 reduces the amyloid plaque burden and improves memory in Alzheimer's disease mouse models. Sci Transl Med 7(309): 309ra164 () pdf(private)

Szaruga M, Veugelen S, Benurwar M, Lismont S, Sepulveda-Falla D, Lleo A, Ryan NS, Lashley T, Fox NC, Murayama S, Gijsen H, De Strooper B, Chávez-Gutiérrez L (2015) Qualitative changes in human γ-secretase underlie familial Alzheimer's disease. J Exp Med 212(12): 2003-13 () pdf(private)


2014 →top

Acx H, Chávez-Gutiérrez L, Serneels L, Lismont S, Benurwar M, Elad N, De Strooper B (2014) Signature amyloid β profiles are produced by different γ-secretase complexes. J Biol Chem 289(7): 4346-55 () pdf(private)

Pimenova AA, Thathiah A, De Strooper B, Tesseur I (2014) Regulation of amyloid precursor protein processing by serotonin signaling. PLoS One 9(1): e87014 () pdf(private)

Lau P, Frigerio CS, De Strooper B (2014) Variance in the identification of microRNAs deregulated in Alzheimer's disease and possible role of lincRNAs in the pathology: the need of larger datasets. Ageing Res Rev : 43-53 () pdf(private)

Morais VA, Haddad D, Craessaerts K, De Bock PJ, Swerts J, Vilain S, Aerts L, Overbergh L, Grünewald A, Seibler P, Klein C, Gevaert K, Verstreken P, De Strooper B (2014) PINK1 loss-of-function mutations affect mitochondrial complex I activity via NdufA10 ubiquinone uncoupling. Science 344(6180): 203-7 () pdf(private)

Cornelissen T, Haddad D, Wauters F, Van Humbeeck C, Mandemakers W, Koentjoro B, Sue C, Gevaert K, De Strooper B, Verstreken P, Vandenberghe W (2014) The deubiquitinase USP15 antagonizes Parkin-mediated mitochondrial ubiquitination and mitophagy. Hum Mol Genet 23(19): 5227-42 () pdf(private)

Martin MG, Ahmed T, Korovaichuk A, Venero C, Menchón SA, Salas I, Munck S, Herreras O, Balschun D, Dotti CG (2014) Constitutive hippocampal cholesterol loss underlies poor cognition in old rodents. EMBO Mol Med 6(7): 902-17 () pdf(private)

Fazzari P, Snellinx A, Sabanov V, Ahmed T, Serneels L, Gartner A, Shariati SA, Balschun D, De Strooper B (2014) Cell autonomous regulation of hippocampal circuitry via Aph1b-γ-secretase/neuregulin 1 signalling. Elife : () pdf(private)

Gärtner A, Fornasiero EF, Valtorta F, Dotti CG (2014) Distinct temporal hierarchies in membrane and cytoskeleton dynamics precede the morphological polarization of developing neurons. J Cell Sci 127(Pt 20): 4409-19 () pdf(private)

Benilova I, Gallardo R, Ungureanu AA, Castillo Cano V, Snellinx A, Ramakers M, Bartic C, Rousseau F, Schymkowitz J, De Strooper B (2014) The Alzheimer disease protective mutation A2T modulates kinetic and thermodynamic properties of amyloid-β (Aβ) aggregation. J Biol Chem 289(45): 30977-89 () pdf(private)

Vilain S, Vanhauwaert R, Maes I, Schoovaerts N, Zhou L, Soukup S, da Cunha R, Lauwers E, Fiers M, Verstreken P (2014) Fast and efficient Drosophila melanogaster gene knock-ins using MiMIC transposons. G3 (Bethesda) 4(12): 2381-7 () pdf(private)

La Fata G, Gärtner A, Domínguez-Iturza N, Dresselaers T, Dawitz J, Poorthuis RB, Averna M, Himmelreich U, Meredith RM, Achsel T, Dotti CG, Bagni C (2014) FMRP regulates multipolar to bipolar transition affecting neuronal migration and cortical circuitry. Nat Neurosci 17(12): 1693-700 () pdf(private)

De Strooper B (2014) Lessons from a failed γ-secretase Alzheimer trial. Cell 159(4): 721-6 () pdf(private)

Fernandes AC, Uytterhoeven V, Kuenen S, Wang YC, Slabbaert JR, Swerts J, Kasprowicz J, Aerts S, Verstreken P (2014) Reduced synaptic vesicle protein degradation at lysosomes curbs TBC1D24/sky-induced neurodegeneration. J Cell Biol 207(4): 453-62 () pdf(private)


2013 →top

Trovò L, Ahmed T, Callaerts-Vegh Z, Buzzi A, Bagni C, Chuah M, Vandendriessche T, D'Hooge R, Balschun D, Dotti CG (2013) Low hippocampal PI(4,5)P₂ contributes to reduced cognition in old mice as a result of loss of MARCKS. Nat Neurosci 16(4): 449-455 () pdf(private)

Jurisch-Yaksi N, Rose AJ, Lu H, Raemaekers T, Munck S, Baatsen P, Baert V, Vermeire W, Scales SJ, Verleyen D, Vandepoel R, Tylzanowski P, Yaksi E, de Ravel T, Yost HJ, Froyen G, Arrington CB, Annaert W (2013) Rer1p maintains ciliary length and signaling by regulating γ-secretase activity and Foxj1a levels. J Cell Biol 200(6): 709-720 () pdf(private)

Khuong TM, Habets RL, Kuenen S, Witkowska A, Kasprowicz J, Swerts J, Jahn R, van den Bogaart G, Verstreken P (2013) Synaptic PI(3,4,5)P3 is required for Syntaxin1A clustering and neurotransmitter release. Neuron 77(6): 1097-1108 () pdf(private)

Barao S, Zhou L, Adamczuk K, Vanhoutvin T, Leuven Fv, Demedts D, Vijverman AC, Bossuyt X, Vandenberghe R, De Strooper B (2013) BACE1 levels correlate with phospho-tau levels in human cerebrospinal fluid. Curr Alzheimer Res 10(7): 671-678 () pdf(private)

van Bon BW, Oortveld MA, Nijtmans LG, Fenckova M, Nijhof B, Besseling J, Vos M, Kramer JM, de Leeuw N, Castells-Nobau A, Asztalos L, Viragh E, Ruiter M, Hofmann F, Eshuis L, Collavin L, Huynen MA, Asztalos Z, Verstreken P, Rodenburg RJ, Smeitink JA, de Vries BB, Schenck A (2013) CEP89 is required for mitochondrial metabolism and neuronal function in man and fly. Hum Mol Genet 22(15): 3138-3151 () pdf(private)

Esposito G, Vos M, Vilain S, Swerts J, De Sousa Valadas J, Van Meensel S, Schaap O, Verstreken P (2013) Aconitase causes iron toxicity in Drosophila pink1 mutants. PLoS Genet 9(4): e1003478 () pdf(private)

Haddad DM, Vilain S, Vos M, Esposito G, Matta S, Kalscheuer VM, Craessaerts K, Leyssen M, Nascimento RM, Vianna-Morgante AM, De Strooper B, Van Esch H, Morais VA, Verstreken P (2013) Mutations in the intellectual disability gene Ube2a cause neuronal dysfunction and impair parkin-dependent mitophagy. Mol Cell 50(6): 831-843 () pdf(private)

Shariati SA, De Strooper B (2013) Redundancy and divergence in the amyloid precursor protein family. FEBS Lett 587(13): 2036-2045 () pdf(private)

Rochin L, Hurbain I, Serneels L, Fort C, Watt B, Leblanc P, Marks MS, De Strooper B, Raposo G, van Niel G (2013) BACE2 processes PMEL to form the melanosome amyloid matrix in pigment cells. Proc Natl Acad Sci U S A 110(26): 10658-10663 () pdf(private)

Iannilli F, Zalfa F, Gartner A, Bagni C, Dotti CG (2013) Cytoplasmic TERT Associates to RNA Granules in Fully Mature Neurons: Role in the Translational Control of the Cell Cycle Inhibitor p15INK4B. PLoS One 8(6): e66602 () pdf(private)

Lau P, Bossers K, Janky R, Salta E, Frigerio CS, Barbash S, Rothman R, Sierksma AS, Thathiah A, Greenberg D, Papadopoulou AS, Achsel T, Ayoubi T, Soreq H, Verhaagen J, Swaab DF, Aerts S, De Strooper B (2013) Alteration of the microRNA network during the progression of Alzheimer's disease. EMBO Mol Med 5(10): 1613-1634 () pdf(private)

Jurisch-Yaksi N, Sannerud R, Annaert W (2013) A fast growing spectrum of biological functions of γ-secretase in development and disease. Biochim Biophys Acta 1828(12): 2815-2827 () pdf(private)

Vos M, Lovisa B, Geens A, Morais VA, Wagnières G, van den Bergh H, Ginggen A, De Strooper B, Tardy Y, Verstreken P (2013) Near-infrared 808 nm light boosts complex IV-dependent respiration and rescues a Parkinson-related pink1 model. PLoS One 8(11): e78562 () pdf(private)

Jurisch-Yaksi N, Annaert W (2013) Protein quality control by Rer1p in the early secretory pathway: from mechanism to implication in Alzheimer's disease. Alzheimers Res Ther 5(6): 61 () pdf(private)


2012 →top

Nesic I, Guix FX, Vennekens K, Michaki V, Van Veldhoven PP, Feiguin F, De Strooper B, Dotti CG, Wahle T (2012) Alterations in phosphatidylethanolamine levels affect the generation of Aβ. Aging Cell 11(1): 63-72 () pdf(private)

Michaki V, Guix FX, Vennekens K, Munck S, Dingwall C, Davis JB, Townsend DM, Tew KD, Feiguin F, De Strooper B, Dotti CG, Wahle T (2012) Down-regulation of the ATP-binding cassette transporter 2 (Abca2) reduces amyloid-β production by altering Nicastrin maturation and intracellular localization. J Biol Chem 287(2): 1100-1111 () pdf(private)

De Strooper B, Iwatsubo T, Wolfe MS (2012) Presenilins and γ-secretase: structure, function, and role in Alzheimer Disease. Cold Spring Harb Perspect Med 2(1): a006304 () pdf(private)

Guix FX, Wahle T, Vennekens K, Snellinx A, Chávez-Gutiérrez L, Ill-Raga G, Ramos-Fernandez E, Guardia-Laguarta C, Lleó A, Arimon M, Berezovska O, Muñoz FJ, Dotti CG, De Strooper B (2012) Modification of γ-secretase by nitrosative stress links neuronal ageing to sporadic Alzheimer's disease. EMBO Mol Med 4(7): 660-673 () pdf(private)

Zhou L, Barão S, Laga M, Bockstael K, Borgers M, Gijsen H, Annaert W, Moechars D, Mercken M, Gevaert K, Gevaer K, De Strooper B (2012) The neural cell adhesion molecules L1 and CHL1 are cleaved by BACE1 protease in vivo. J Biol Chem 287(31): 25927-25940 () pdf(private)

Coen K, Flannagan RS, Baron S, Carraro-Lacroix LR, Wang D, Vermeire W, Michiels C, Munck S, Baert V, Sugita S, Wuytack F, Hiesinger PR, Grinstein S, Annaert W (2012) Lysosomal calcium homeostasis defects, not proton pump defects, cause endo-lysosomal dysfunction in PSEN-deficient cells. J Cell Biol 198(1): 23-35 () pdf(private)

Raemaekers T, Peric A, Baatsen P, Sannerud R, Declerck I, Baert V, Michiels C, Annaert W (2012) ARF6-mediated endosomal transport of Telencephalin affects dendritic filopodia-to-spine maturation. EMBO J 31(15): 3252-3269 () pdf(private)