Inter-University Attraction Poles Phase VII P7/16 Network: An integrated approach towards understanding the pathogenesis of neurodegeneration





Home IAP NEUROBRAINNET network Project Scientific Publications Reports & Activities

IAP VII P7/16 Publications

P4. Wim Robberecht


→2016   →2015   →2014   →2013   →2012   

2016 →top

Van Laere K, Wilms G, Van Damme P (2016) Neurological picture. FDG-PET findings in three cases of Mills' syndrome. J Neurol Neurosurg Psychiatry 87(2): 222-3 () pdf(private)

Bednarska NG, van Eldere J, Gallardo R, Ganesan A, Ramakers M, Vogel I, Baatsen P, Staes A, Goethals M, Hammarström P, Nilsson KP, Gevaert K, Schymkowitz J, Rousseau F (2016) Protein aggregation as an antibiotic design strategy. Mol Microbiol 99(5): 849-65 () pdf(private)

Shen S, Benoy V, Bergman JA, Kalin JH, Frojuello M, Vistoli G, Haeck W, Van Den Bosch L, Kozikowski AP (2016) Bicyclic-Capped Histone Deacetylase 6 Inhibitors with Improved Activity in a Model of Axonal Charcot-Marie-Tooth Disease. ACS Chem Neurosci 7(2): 240-58 () pdf(private)

Schymkowitz J, Rousseau F (2016) Protein aggregation: A rescue by chaperones. Nat Chem Biol 12(2): 58-9 () pdf(private)

De Vreese R, Depetter Y, Verhaeghe T, Desmet T, Benoy V, Haeck W, Van Den Bosch L, D Hooghe M (2016) Synthesis and SAR assessment of novel Tubathian analogs in the pursuit of potent and selective HDAC6 inhibitors. Org Biomol Chem 14(8): 2537-49 () pdf(private)

Ganesan A, Siekierska A, Beerten J, Brams M, Van Durme J, De Baets G, Van der Kant R, Gallardo R, Ramakers M, Langenberg T, Wilkinson H, De Smet F, Ulens C, Rousseau F, Schymkowitz J (2016) Structural hot spots for the solubility of globular proteins. Nat Commun : 10816 () pdf(private)


2015 →top

Ganesan A, Debulpaep M, Wilkinson H, Van Durme J, De Baets G, Jonckheere W, Ramakers M, Ivarsson Y, Zimmermann P, Van Eldere J, Schymkowitz J, Rousseau F (2015) Selectivity of aggregation-determining interactions. J Mol Biol 427(2): 236-47 () pdf(private)

Raitano S, Ordovàs L, De Muynck L, Guo W, Espuny-Camacho I, Geraerts M, Khurana S, Vanuytsel K, Tóth BI, Voets T, Vandenberghe R, Cathomen T, Van Den Bosch L, Vanderhaeghen P, Van Damme P, Verfaillie CM (2015) Restoration of progranulin expression rescues cortical neuron generation in an induced pluripotent stem cell model of frontotemporal dementia. Stem Cell Reports 4(1): 16-24 () pdf(private)

Sabate R, Rousseau F, Schymkowitz J, Ventura S (2015) What makes a protein sequence a prion? PLoS Comput Biol 11(1): e1004013 () pdf(private)

Cho KJ, Schepens B, Seok JH, Kim S, Roose K, Lee JH, Gallardo R, Van Hamme E, Schymkowitz J, Rousseau F, Fiers W, Saelens X, Kim KH (2015) Structure of the extracellular domain of matrix protein 2 of influenza A virus in complex with a protective monoclonal antibody. J Virol 89(7): 3700-11 () pdf(private)

De Baets G, Van Durme J, van der Kant R, Schymkowitz J, Rousseau F (2015) Solubis: optimize your protein. Bioinformatics 31(15): 2580-2 () pdf(private)

Sabate R, Rousseau F, Schymkowitz J, Batlle C, Ventura S (2015) Amyloids or prions? That is the question. Prion 9(3): 200-6 () pdf(private)

Staats KA, Schönefeldt S, Van Helleputte L, Van Rillaer M, Lampi Y, Dooley J, Van Den Bosch L, Liston A (2015) C-kit is important for SOD1(G93A) mouse survival independent of mast cells. Neuroscience : 415-20 () pdf(private)

Chabwine JN, Talavera K, Van Den Bosch L, Callewaert G (2015) NKCC1 downregulation induces hyperpolarizing shift of GABA responsiveness at near term fetal stages in rat cultured dorsal root ganglion neurons. BMC Neurosci : 41 () pdf(private)

Gemayel R, Chavali S, Pougach K, Legendre M, Zhu B, Boeynaems S, van der Zande E, Gevaert K, Rousseau F, Schymkowitz J, Babu MM, Verstrepen KJ (2015) Variable Glutamine-Rich Repeats Modulate Transcription Factor Activity. Mol Cell 59(4): 615-27 () pdf(private)

Jovičić A, Mertens J, Boeynaems S, Bogaert E, Chai N, Yamada SB, Paul JW, Sun S, Herdy JR, Bieri G, Kramer NJ, Gage FH, Van Den Bosch L, Robberecht W, Gitler AD (2015) Modifiers of C9orf72 dipeptide repeat toxicity connect nucleocytoplasmic transport defects to FTD/ALS. Nat Neurosci 18(9): 1226-9 () pdf(private)

Ordovás L, Boon R, Pistoni M, Chen Y, Wolfs E, Guo W, Sambathkumar R, Bobis-Wozowicz S, Helsen N, Vanhove J, Berckmans P, Cai Q, Vanuytsel K, Eggermont K, Vanslembrouck V, Schmidt BZ, Raitano S, Van Den Bosch L, Nahmias Y, Cathomen T, Struys T, Verfaillie CM (2015) Efficient Recombinase-Mediated Cassette Exchange in hPSCs to Study the Hepatocyte Lineage Reveals AAVS1 Locus-Mediated Transgene Inhibition. Stem Cell Reports 5(5): 918-31 () pdf(private)


2014 →top

Zhao H, Race V, Matthijs G, De Jonghe P, Robberecht W, Lambrechts D, Van Damme P (2014) Exome sequencing reveals HINT1 mutations as a cause of distal hereditary motor neuropathy. Eur J Hum Genet 22(6): 847-50 () pdf(private)

Goris A, van Setten J, Diekstra F, Ripke S, Patsopoulos NA, Sawcer SJ, , van Es M, , Andersen PM, Melki J, Meininger V, Hardiman O, Landers JE, Brown RH, Shatunov A, Leigh N, Al-Chalabi A, Shaw CE, Traynor BJ, Chiò A, Restagno G, Mora G, Ophoff RA, Oksenberg JR, Van Damme P, Compston A, Robberecht W, Dubois B, van den Berg LH, De Jager PL, Veldink JH, de Bakker PI (2014) No evidence for shared genetic basis of common variants in multiple sclerosis and amyotrophic lateral sclerosis. Hum Mol Genet 23(7): 1916-22 () pdf(private)

Fogh I, Ratti A, Gellera C, Lin K, Tiloca C, Moskvina V, Corrado L, Sorarù G, Cereda C, Corti S, Gentilini D, Calini D, Castellotti B, Mazzini L, Querin G, Gagliardi S, Del Bo R, Conforti FL, Siciliano G, Inghilleri M, Saccà F, Bongioanni P, Penco S, Corbo M, Sorbi S, Filosto M, Ferlini A, Di Blasio AM, Signorini S, Shatunov A, Jones A, Shaw PJ, Morrison KE, Farmer AE, Van Damme P, Robberecht W, Chiò A, Traynor BJ, Sendtner M, Melki J, Meininger V, Hardiman O, Andersen PM, Leigh NP, Glass JD, Overste D, Diekstra FP, Veldink JH, van Es MA, Shaw CE, Weale ME, Lewis CM, Williams J, Brown RH, Landers JE, Ticozzi N, Ceroni M, Pegoraro E, Comi GP, D'Alfonso S, van den Berg LH, Taroni F, Al-Chalabi A, Powell J, Silani V, (2014) A genome-wide association meta-analysis identifies a novel locus at 17q11.2 associated with sporadic amyotrophic lateral sclerosis. Hum Mol Genet 23(8): 2220-31 () pdf(private)

Van Laere K, Vanhee A, Verschueren J, De Coster L, Driesen A, Dupont P, Robberecht W, Van Damme P (2014) Value of 18fluorodeoxyglucose-positron-emission tomography in amyotrophic lateral sclerosis: a prospective study. JAMA Neurol 71(5): 553-61 () pdf(private)

De Baets G, Van Durme J, Rousseau F, Schymkowitz J (2014) A genome-wide sequence-structure analysis suggests aggregation gatekeepers constitute an evolutionary constrained functional class. J Mol Biol 426(12): 2405-12 () pdf(private)

Van Damme P, Robberecht W (2014) Developments in treatments for amyotrophic lateral sclerosis via intracerebroventricular or intrathecal delivery. Expert Opin Investig Drugs 23(7): 955-63 () pdf(private)

van Doormaal PT, Ticozzi N, Gellera C, Ratti A, Taroni F, Chiò A, Calvo A, Mora G, Restagno G, Traynor BJ, Birve A, Lemmens R, van Es MA, Saris CG, Blauw HM, van Vught PW, Groen EJ, Corrado L, Mazzini L, Del Bo R, Corti S, Waibel S, Meyer T, Ludolph AC, Goris A, van Damme P, Robberecht W, Shatunov A, Fogh I, Andersen PM, D'Alfonso S, Hardiman O, Cronin S, Rujescu D, Al-Chalabi A, Landers JE, Silani V, van den Berg LH, Veldink JH (2014) Analysis of the KIFAP3 gene in amyotrophic lateral sclerosis: a multicenter survival study. Neurobiol Aging 35(10): 2420.e13-4 () pdf(private)

Megens S, Vaira D, De Baets G, Dekeersmaeker N, Schrooten Y, Li G, Schymkowitz J, Rousseau F, Vandamme AM, Moutschen M, Van Laethem K (2014) Horizontal gene transfer from human host to HIV-1 reverse transcriptase confers drug resistance and partly compensates for replication deficits. Virology : 310-8 () pdf(private)

Diekstra FP, Van Deerlin VM, van Swieten JC, Al-Chalabi A, Ludolph AC, Weishaupt JH, Hardiman O, Landers JE, Brown RH, van Es MA, Pasterkamp RJ, Koppers M, Andersen PM, Estrada K, Rivadeneira F, Hofman A, Uitterlinden AG, van Damme P, Melki J, Meininger V, Shatunov A, Shaw CE, Leigh PN, Shaw PJ, Morrison KE, Fogh I, Chiò A, Traynor BJ, Czell D, Weber M, Heutink P, de Bakker PI, Silani V, Robberecht W, van den Berg LH, Veldink JH (2014) C9orf72 and UNC13A are shared risk loci for amyotrophic lateral sclerosis and frontotemporal dementia: a genome-wide meta-analysis. Ann Neurol 76(1): 120-33 () pdf(private)

Herdewyn S, Cirillo C, Van Den Bosch L, Robberecht W, Vanden Berghe P, Van Damme P (2014) Prevention of intestinal obstruction reveals progressive neurodegeneration in mutant TDP-43 (A315T) mice. Mol Neurodegener : 24 () pdf(private)

Poppe L, Rué L, Robberecht W, Van Den Bosch L (2014) Translating biological findings into new treatment strategies for amyotrophic lateral sclerosis (ALS). Exp Neurol : 138-51 () pdf(private)

Nonneman A, Robberecht W, Van Den Bosch L (2014) The role of oligodendroglial dysfunction in amyotrophic lateral sclerosis. Neurodegener Dis Manag 4(3): 223-39 () pdf(private)

Swinnen B, Robberecht W (2014) The phenotypic variability of amyotrophic lateral sclerosis. Nat Rev Neurol 10(11): 661-70 () pdf(private)


2013 →top

Morris KL, Rodger A, Hicks MR, Debulpaep M, Schymkowitz J, Rousseau F, Serpell LC (2013) Exploring the sequence-structure relationship for amyloid peptides. Biochem J 450(2): 275-283 () pdf(private)

Taes I, Timmers M, Hersmus N, Bento-Abreu A, Van Den Bosch L, Van Damme P, Auwerx J, Robberecht W (2013) Hdac6 deletion delays disease progression in the SOD1G93A mouse model of ALS. Hum Mol Genet 22(9): 1783-1790 () pdf(private)

Philips T, Bento-Abreu A, Nonneman A, Haeck W, Staats K, Geelen V, Hersmus N, Küsters B, Van Den Bosch L, Van Damme P, Richardson WD, Robberecht W (2013) Oligodendrocyte dysfunction in the pathogenesis of amyotrophic lateral sclerosis. Brain 136(Pt 2): 471-482 () pdf(private)

Herbert C, Schieborr U, Saxena K, Juraszek J, De Smet F, Alcouffe C, Bianciotto M, Saladino G, Sibrac D, Kudlinzki D, Sreeramulu S, Brown A, Rigon P, Herault JP, Lassalle G, Blundell TL, Rousseau F, Gils A, Schymkowitz J, Tompa P, Herbert JM, Carmeliet P, Gervasio FL, Schwalbe H, Bono F (2013) Molecular mechanism of SSR128129E, an extracellularly acting, small-molecule, allosteric inhibitor of FGF receptor signaling. Cancer Cell 23(4): 489-501 () pdf(private)

De Muynck L, Herdewyn S, Beel S, Scheveneels W, Van Den Bosch L, Robberecht W, Van Damme P (2013) The neurotrophic properties of progranulin depend on the granulin E domain but do not require sortilin binding. Neurobiol Aging 34(11): 2541-2547 () pdf(private)

Debray S, Race V, Crabbé V, Herdewyn S, Matthijs G, Goris A, Dubois B, Thijs V, Robberecht W, Van Damme P (2013) Frequency of C9orf72 repeat expansions in amyotrophic lateral sclerosis: a Belgian cohort study. Neurobiol Aging 34(12): 2890.e7-2890.e12 () pdf(private)

Bednarska NG, Schymkowitz J, Rousseau F, Van Eldere J (2013) Protein aggregation in bacteria: the thin boundary between functionality and toxicity. Microbiology 159(Pt 9): 1795-1806 () pdf(private)

Van Damme P, Robberecht W (2013) Clinical implications of recent breakthroughs in amyotrophic lateral sclerosis. Curr Opin Neurol 26(5): 466-472 () pdf(private)

Staats KA, Van Helleputte L, Jones AR, Bento-Abreu A, Van Hoecke A, Shatunov A, Simpson CL, Lemmens R, Jaspers T, Fukami K, Nakamura Y, Brown RH, Van Damme P, Liston A, Robberecht W, Al-Chalabi A, Van Den Bosch L (2013) Genetic ablation of phospholipase C delta 1 increases survival in SOD1(G93A) mice. Neurobiol Dis : 11-17 () pdf(private)

Staats KA, Hernandez S, Schönefeldt S, Bento-Abreu A, Dooley J, Van Damme P, Liston A, Robberecht W, Van Den Bosch L (2013) Rapamycin increases survival in ALS mice lacking mature lymphocytes. Mol Neurodegener : 31 () pdf(private)

Staats KA, Schönefeldt S, Van Rillaer M, Van Hoecke A, Van Damme P, Robberecht W, Liston A, Van Den Bosch L (2013) Beta-2 microglobulin is important for disease progression in a murine model for amyotrophic lateral sclerosis. Front Cell Neurosci : 249 () pdf(private)


2012 →top

Diekstra FP, van Vught PW, van Rheenen W, Koppers M, Pasterkamp RJ, van Es MA, Schelhaas HJ, de Visser M, Robberecht W, Van Damme P, Andersen PM, van den Berg LH, Veldink JH (2012) UNC13A is a modifier of survival in amyotrophic lateral sclerosis. Neurobiol Aging 33(3): 630.e3-8 () pdf(private)

Herdewyn S, Zhao H, Moisse M, Race V, Matthijs G, Reumers J, Kusters B, Schelhaas HJ, van den Berg LH, Goris A, Robberecht W, Lambrechts D, Van Damme P (2012) Whole-genome sequencing reveals a coding non-pathogenic variant tagging a non-coding pathogenic hexanucleotide repeat expansion in C9orf72 as cause of amyotrophic lateral sclerosis. Hum Mol Genet 21(11): 2412-2419 () pdf(private)

Staats KA, Van Rillaer M, Scheveneels W, Verbesselt R, Van Damme P, Robberecht W, Van Den Bosch L (2012) Dantrolene is neuroprotective in vitro, but does not affect survival in SOD1(G⁹³A) mice. Neuroscience : 26-31 () pdf(private)

Van Hoecke A, Schoonaert L, Lemmens R, Timmers M, Staats KA, Laird AS, Peeters E, Philips T, Goris A, Dubois B, Andersen PM, Al-Chalabi A, Thijs V, Turnley AM, van Vught PW, Veldink JH, Hardiman O, Van Den Bosch L, Gonzalez-Perez P, Van Damme P, Brown RH, van den Berg LH, Robberecht W (2012) EPHA4 is a disease modifier of amyotrophic lateral sclerosis in animal models and in humans. Nat Med 18(9): 1418-1422 () pdf(private)

Staats KA, Bogaert E, Hersmus N, Jaspers T, Luyten T, Bultynck G, Parys JB, Hisatsune C, Mikoshiba K, Van Damme P, Robberecht W, Van Den Bosch L (2012) Neuronal overexpression of IP₃ receptor 2 is detrimental in mutant SOD1 mice. Biochem Biophys Res Commun 429(3-4): 210-213 () pdf(private)

Beerten J, Schymkowitz J, Rousseau F (2012) Aggregation prone regions and gatekeeping residues in protein sequences. Curr Top Med Chem 12(22): 2470-2478 () pdf(private)