Inter-University Attraction Poles Phase VII P7/16 Network: An integrated approach towards understanding the pathogenesis of neurodegeneration

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IAP VII P7/16 Publications

P5. Jean-Noel Octave

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2016 →top

Stanga S, Zanou N, Audouard E, Tasiaux B, Contino S, Vandermeulen G, René F, Loeffler JP, Clotman F, Gailly P, Dewachter I, Octave JN, Kienlen-Campard P (2016) APP-dependent glial cell line-derived neurotrophic factor gene expression drives neuromuscular junction formation. FASEB J 30(5): 1696-711 () pdf(private)

Vasconcelos B, Stancu IC, Buist A, Bird M, Wang P, Vanoosthuyse A, Van Kolen K, Verheyen A, Kienlen-Campard P, Octave JN, Baatsen P, Moechars D, Dewachter I (2016) Heterotypic seeding of Tau fibrillization by pre-aggregated Abeta provides potent seeds for prion-like seeding and propagation of Tau-pathology in vivo. Acta Neuropathol 131(4): 549-69 () pdf(private)

Couturier J, Stancu IC, Schakman O, Pierrot N, Huaux F, Kienlen-Campard P, Dewachter I, Octave JN (2016) Activation of phagocytic activity in astrocytes by reduced expression of the inflammasome component ASC and its implication in a mouse model of Alzheimer disease. J Neuroinflammation : 20 () pdf(private)

Decock M, Stanga S, Octave JN, Dewachter I, Smith SO, Constantinescu SN, Kienlen-Campard P (2016) Glycines from the APP GXXXG/GXXXA Transmembrane Motifs Promote Formation of Pathogenic Abeta Oligomers in Cells. Frontiers in Aging Neuroscience : 1-15 () pdf(private)

2015 →top

Marinangeli C, Tasiaux B, Opsomer R, Hage S, Sodero AO, Dewachter I, Octave JN, Smith SO, Constantinescu SN, Kienlen-Campard P (2015) Presenilin transmembrane domain 8 conserved AXXXAXXXG motifs are required for the activity of the γ-secretase complex. J Biol Chem 290(11): 7169-84 () pdf(private)

Hage S, Stanga S, Marinangeli C, Octave JN, Dewachter I, Quetin-Leclercq J, Kienlen-Campard P (2015) Characterization of Pterocarpus erinaceus kino extract and its gamma-secretase inhibitory properties. J Ethnopharmacol : 192-202 () pdf(private)

Stancu IC, Vasconcelos B, Ris L, Wang P, Villers A, Peeraer E, Buist A, Terwel D, Baatsen P, Oyelami T, Pierrot N, Casteels C, Bormans G, Kienlen-Campard P, Octave JN, Moechars D, Dewachter I (2015) Templated misfolding of Tau by prion-like seeding along neuronal connections impairs neuronal network function and associated behavioral outcomes in Tau transgenic mice. Acta Neuropathol 129(6): 875-94 () pdf(private)

Decock M, El Haylani L, Stanga S, Dewachter I, Octave JN, Smith SO, Constantinescu SN, Kienlen-Campard P (2015) Analysis by a highly sensitive split luciferase assay of the regions involved in APP dimerization and its impact on processing. FEBS Open Bio : 763-73 () pdf(private)

2014 →top

Hage S, Marinangeli C, Stanga S, Octave JN, Quetin-Leclercq J, Kienlen-Campard P (2014) Gamma-secretase inhibitor activity of a Pterocarpus erinaceus extract. Neurodegener Dis 14(1): 39-51 () pdf(private)

Tang TC, Hu Y, Kienlen-Campard P, El Haylani L, Decock M, Van Hees J, Fu Z, Octave JN, Constantinescu SN, Smith SO (2014) Conformational changes induced by the A21G Flemish mutation in the amyloid precursor protein lead to increased Aβ production. Structure 22(3): 387-96 () pdf(private)

Stancu IC, Ris L, Vasconcelos B, Marinangeli C, Goeminne L, Laporte V, Haylani LE, Couturier J, Schakman O, Gailly P, Pierrot N, Kienlen-Campard P, Octave JN, Dewachter I (2014) Tauopathy contributes to synaptic and cognitive deficits in a murine model for Alzheimer's disease. FASEB J 28(6): 2620-31 () pdf(private)

Pierrot N, Octave JN (2014) [Cholesterol, neuronal activity and Alzheimer disease]. Med Sci (Paris) 30(3): 244-6 () pdf(private)

Rabolli V, Wallemme L, Lo Re S, Uwambayinema F, Palmai-Pallag M, Thomassen L, Tyteca D, Octave JN, Marbaix E, Lison D, Devuyst O, Huaux F (2014) Critical role of aquaporins in interleukin 1β (IL-1β)-induced inflammation. J Biol Chem 289(20): 13937-47 () pdf(private)

Hendrickx A, Pierrot N, Tasiaux B, Schakman O, Kienlen-Campard P, De Smet C, Octave JN (2014) Epigenetic regulations of immediate early genes expression involved in memory formation by the amyloid precursor protein of Alzheimer disease. PLoS One 9(6): e99467 () pdf(private)

Stancu IC, Vasconcelos B, Terwel D, Dewachter I (2014) Models of β-amyloid induced Tau-pathology: the long and "folded" road to understand the mechanism. Mol Neurodegener : 51 () pdf(private)

2013 →top

Octave JN, Pierrot N, Ferao Santos S, Nalivaeva NN, Turner AJ (2013) From synaptic spines to nuclear signaling: nuclear and synaptic actions of the amyloid precursor protein. J Neurochem 126(2): 183-90 () pdf(private)

2012 →top

Ben Khalifa N, Tyteca D, Marinangeli C, Depuydt M, Collet JF, Courtoy PJ, Renauld JC, Constantinescu S, Octave JN, Kienlen-Campard P (2012) Structural features of the KPI domain control APP dimerization, trafficking, and processing. FASEB J 26(2): 855-867 () pdf(private)

Ben Khalifa N, Tyteca D, Courtoy PJ, Renauld JC, Constantinescu SN, Octave JN, Kienlen-Campard P (2012) Contribution of Kunitz protease inhibitor and transmembrane domains to amyloid precursor protein homodimerization. Neurodegener Dis 10(1-4): 92-95 () pdf(private)

2011 →top

Oosterlinck WW, Dresselaers T, Geldhof V, Van Santvoort A, Robberecht W, Herijgers P, Himmelreich U (2011) Response of mouse brain perfusion to hypo- and hyperventilation measured by arterial spin labeling. Magn Reson Med 66(3): 802-11 () pdf(private)